Syntheses of Analgesics. XX

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A load estimation algorithm based on k-means cluster analysis was developed. The algorithm applies cluster centres – of previously clustered load profiles – and distance functions to estimate missing and future measurements. Canberra, Manhattan, Euclidean, and Pearson correlation distances were investigated. Several case studies were implemented using daily and segmented load profiles of aggreg...

Rr Xx-xx

The growing availability of low-power sensors, microprocessors, and transmitters makes it increasingly attractive to use distributed sensor networks for track-health monitoring. Widespread implementation of these networks will require robust and low-maintenance methods for powering the electronics. This research investigates two principal methods of harvesting mechanical power from passing rail...

Submitted xxxx; Revised xxxx; Published xx/xx

Opioid Analgesics

Intensive research on the neurobiology of pain over the past two decades has revealed many receptors, ion channels and enzymes with potential as novel targets for development of a new generation of analgesic agents. However, despite large investment in preclinical and clinical development of small molecules and biologics as potential novel pain therapeutics, very few have reached the clinic. He...

Topical analgesics.

BACKGROUND AND OBJECTIVES Pain treatment involves the usage of common and opioid analgesics, nonsteroidal anti-inflammatory drugs (NSAIDs) and adjuvant analgesics. Traditionally, these drugs are administered systemically or into the neuraxis. However, when analgesics are applied through these pathways, they are associated with significant side effects, which can hinder its use. Topical administ...